Fig. 6

Atherosclerotic plaque accumulation in the root, arch, thoracic, and abdominal aortic segments. Representative images of plaque accumulation in Western diet-fed groups at 7 months of age in the aortic root, scale bar 250 μm (a) and aortic segments: arch, thoracic, and abdominal (left to right), scale bar 0.5 cm (b). Quantification plaque area in the aortic root (c) and plaque percentage in aortic segments of Western diet-fed groups at 4 (d) and 7 months of age (e), as well as chow-fed groups at 7 months (f). Chow: WT (n = 3), ApoE (n = 5), mdx (n = 4), and mdx-ApoE (n = 4–7). Western: WT 4 m (n = 3–4), 7 m (n = 5–7); ApoE 4 m (n = 4), 7 m (n = 5–7); mdx 4 m (n = 2–5), 7 m (n = 3–4); and mdx-ApoE 4 m (n = 5–6), 7 m (n = 5–6). Mean + SEM. *P < 0.05 compared to WT and mdx #P < 0.05 compared to all other groups