Fig. 3

Increased mitochondrial biogenesis and respiratory function in skeletal muscle of MKP-5-deficient mice. Relative mRNA expression of genes associated with mitochondrial biogenesis in soleus muscle in (a) uninjured and (b) 10 days after CTX-induced injury. Mitochondrial DNA content determined by mitochondrial DNA copy number in the soleus muscle of (c) uninjured and (d) 10 days after CTX-induced injury. ADP-stimulated respiration (state 3), basal respiration (state 4), and respiratory control ratio (RCR; state 3/state 4) in soleus muscle in (e, f, g) uninjured and at (h, i, j ) 10 days after CTX-induced injury. *P < 0.05, **P < 0.01, n = 5 per genotype