Fig. 4
From: Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle
Assessment of mitochondria-associated cell signalling in C57BL/10, mdx, dko and mdx-Fiona mice. Representative images and quantification of a Sirtuin 1 (Sirt 1), normalised to loading control (total protein stain; TPS), and b phosphorylation status of AMP-activated protein kinase (AMPK), normalised to total protein expression of AMPK, in quadriceps muscles from C57BL/10 (C57), mdx, dko and mdx-Fiona (mdx-Fio) mice. Gene expression of c proliferator-activated receptor gamma coactivator (PGC) -1α and d PGC-1β in tibialis anterior muscles from C57, mdx, dko and mdx-Fio mice. Data are represented as mean ± SEM, * denotes significance set at P < 0.05. Representative image n = 3/group, quantification generated from n = 5-6/group