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Fig. 1 | Skeletal Muscle

Fig. 1

From: Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice

Fig. 1

Body weight, KI, serum CK levels, and necrotic area in the quadriceps muscle. a Average body weight of mice at 90 days of age (n = 8 per group). b Radiographs of dKO mice treated with rat IgG or MR16-1. KI was measured using the radiographs. c KI of rat IgG dKO mice (n = 5) and MR16-1-treated dKO mice (n = 8). No significant difference was observed in the average KI between the two groups. d Serum CK levels of the mice at 90 days of age (n = 7–8). e A representative image of anti-mouse IgG-positive necrotic area in the quadriceps muscle. f The percentage of necrotic fibers/total fibers (× 200 magnification). Necrosis was significantly reduced in dKO mice by MR16-1 treatment. *P < 0.05

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