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Fig. 6 | Skeletal Muscle

Fig. 6

From: Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice

Fig. 6

The effects of MR16-1 treatment on fibrosis in the quadriceps muscle. a A representative image of double staining of periostin and PDGFRα in the quadriceps muscle. PDGFRα-positive cells were co-localized with periostin-positive fibrotic area. b The quantification of fibrotic area of muscle sections positive for Masson’s trichrome, and c periostin. d Western blot analysis of periostin and PDGFRα expression (n = 6 per group). e The expression levels of periostin and f PDGFRα, normalized by GAPDH, of dKO mice treated with rat IgG or MR16-1 were compared. g The levels of fibrosis-related genes (Col1a1, Col3a1, Col5a1, Fn1, Eln, Lum, Mmp1, Mmp2, Timp1, and Timp2, normalized by Lbr) were measured. The levels were expressed as fold increase of wild-type mice (n = 3–4 per group). *P < 0.05, **P < 0.01

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Skeletal Muscle

ISSN: 2044-5040

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