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Fig. 2 | Skeletal Muscle

Fig. 2

From: A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

Fig. 2

Effect of mRK35 in mdx mice. a Weekly body weights following intraperitoneal administration of 10 mg/kg/week mRK35 or vehicle (PBS) in 8-week-old male mdx mice. b Forelimb grip strength measured after 8 weeks of treatment. c Tissue wet weights of the TA, gastrocnemius, and quadriceps muscles. d Tissue wet weight of the EDL. e EDL maximum tetanic force from resting length. f EDL cross-sectional area. g EDL specific force. Treatment groups contained 9 (vehicle) or 10 (mRK35) treated mice. Data plotted are means ± SEM. *p < 0.05 versus vehicle as measured by two-tailed Student’s t test

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Skeletal Muscle

ISSN: 2044-5040

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