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Fig. 11 | Skeletal Muscle

Fig. 11

From: The breaking and making of healthy adult human skeletal muscle in vivo

Fig. 11

Myotube formation in vivo. a Single slice from a confocal stack of images of a regenerating zone of human skeletal muscle (day 7), capturing 6–7 adjoining nuclei (green) enclosed in a CD56+ (magenta) structure (arrow), likely a myotube, which is aligned along the fibre axis. Note the faintly visible adjoining uninjured fibre underneath, and part of another regenerating fibre at the bottom left of the image. The dashed line indicates the location of the YZ orthogonal view, where the fine CD56 staining can be seen entirely surrounding the myotube and where 2 peripherally located myonuclei are visible in the undamaged fibre. b Confocal images of 2 biopsy cross sections, from the same individual as in a, stained for CD56 and desmin, where CD56 can be seen encasing desmin+ structures, in 3 regenerating fibres (arrows) in each series of images. Scale bars, 20 μm

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