Impaired regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis

Table 1 Gastrocnemius muscle fiber size in CAPN3-KO and wild type mice

	Baseline		4 weeks		12 weeks
	Number per square millimeter	Diameter (μm)	Number per square millimeter	Diameter (μm)	Number per square millimeter	Diameter (μm)
CAPN3-KO
STO	158	31.16 ± 0.4	647	23.1 ± 0.3****	633	24.1 ± 0.3****
FTG/O	316	40.81 ± 0.4	240	28.8 ± 0.6	153	35.8 ± 0.9**
All fibers	474	37.92 ± 0.3	887	24.6 ± 0.3****	786	26.4 ± 0.3****
Wild Type
STO	132	36.92 ± 0.5	466	26.2 ± 0.4	321	29.9 ± 0.4
FTG/O	230	45.35 ± 0.4	256	29.9 ± 0.6	183	39.6 ± 0.7
All fibers	362	42.27 ± 0.4	724	27.5 ± 0.3	504	33.3 ± 0.4

ISSN: 2044-5040