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Table 2 Tibialis anterior muscle fiber size in CAPN3-KO mice following gene therapy

From: Impaired regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis

CAPN3-KO

Untreated-TA

AAV.CAPN3.wt-treated TA

Number per square millimeter

Diameter

(μm)

Number per square millimeter

Diameter

(μm)

STO

355

32.72 ± 0.4

223

39.81 ± 0.6****

FTG/O

116

44.26 ± 0.9

99

50.40 ± 1.2****

All fibers

471

35.55 ± 0.4

322

43.08 ± 0.6****

  1. **** P < 0.0001 compared to untreated parameter