Fig. 8
From: Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation
Model of Nilotinib effects on myoblasts and skeletal myogenesis. Nilotinib binds to and inhibits p38 MAPK. Consequently, Nilotinib activates the MEK/ERK proliferation signaling inhibiting myoblast differentiation. Simultaneously, Nilotinib stimulates the AKT survival pathway. In addition, ERK1/2 and AKT stimulation is required for Nilotinib-induced myoblast proliferation. The stimulation of proliferation and the anti-myogenic effects of Nilotinib through the perturbation of p38, ERK, and AKT signaling pathways are illustrated