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Table 2 Body, muscle, and organ weights normalized by body weight in P448Lneo (FKRP) and control (BL6) mice showing significant differences at 6 and 9 months of age

From: Skeletal, cardiac, and respiratory muscle function and histopathology in the P448Lneo− mouse model of FKRP-deficient muscular dystrophy

Weight
(n = 8)
1 month 2 months 6 months 9 months
BL6 FKRP BL6 FKRP BL6 FKRP BL6 FKRP
Body (g) 19 ± 1.2 19.6 ± 0.9 21.9 ± 1.5 22.3 ± 0.83 28 ± 1.7 30 ± 1.2 33 ± 6.0 31 ± 1.7
GAS/BW(10−6) 6.2 ± 0.5 6.3 ± 0.3 6.4 ± 0.4 6.5 ± 0.4 5.4 ± 1 6.0 ± 0.2*** 5.0 ± 0.2 6.3 ± 0.5***
Sol/BW(10−7) 3.7 ± 0.3 3.7 ± 0.2 3.8 ± 0.9 3.6 ± 0.5 3.0 ± 0.4 3.5 ± 0.2* 3.3 ± 0.3 4.1 ± 0.4**
TA/BW(10−6) 2.4 ± 0.4 2.3 ± 0.2 2.3 ± 0.1 2.3 ± 0.2 1.8 ± 0.2 2.2 ± 0.2*** 1.4 ± 0.2 2.0 ± 0.3***
Triceps/BW(10−6) 4.1 ± 0.4 4.4 ± 0.4 4.4 ± 0.6 4.3 ± 0.4 3.4 ± 0.6 4.5 ± 0.3*** 3.3 ± 0.6 5.4 ± 0.9***
Quad/BW(10−6) 7.0 ± 0.2 7.3 ± 1.1 5.7 ± 0.8 6.0 ± 0.8 5.3 ± 0.8 6.5 ± 0.9* 5.0 ± 0.9 6.3 ± 0.4**
Heart/BW(10−6) 5.0 ± 0.2 5.3 ± 0.5 5.1 ± 0.2 5.2 ± 0.4 4.3 ± 0.3 4.4 ± 0.2 3.9 ± 0.5 4.4 ± 0.4*
Brain/BW(10−6) 21 ± 1.2 20 ± 3.6 20 ± 1.4 19 ± 1 16 ± 1.2 15 ± 0.5* 14.5 ± 2.8 14.2 ± 0.1
  1. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; using t test when compared to BL6 control mice at same age. Data presented as mean ± SD. GAS gastrocnemius, Sol soleus, TA tibialis anterior, Quad quadriceps, BW body weight