Measurement | BL6 control | FKRP | FKRP-treadmill | Significantly different groups (adjusted p values using ANOVA followed by post hoc analysis) | ||||
---|---|---|---|---|---|---|---|---|
N | Mean ± SD | N | Mean ± SD | N | Mean ± SD | |||
Inflammation (foci/mm2) | GAS | 8 | 0.03 ± 0.03 | 8 | 0.5 ± 0.4 | 12 | 0.9 ± 0.3 | #BL6 vs FKRP-treadmill: p < 0.0001 |
Quad | 8 | 0.05 ± 0.04 | 8 | 0.6 ± 0.2 | 12 | 1.1 ± 0.5 | #BL6 vs FKRP: p < 0.01, #BL6 vs FKRP-treadmill: p < 0.0001 | |
Triceps | 8 | 0.04 ± 0.06 | 8 | 0.6 ± 0.4 | 12 | 1.1 ± 0.3 | #BL6 vs FKRP: p < 0.01, #BL6 vs FKRP-treadmill: p < 0.0001 | |
% fibrosis | Quad | 8 | 0.29 ± 0.07 | 8 | 0.41 ± 0.18 | 12 | 0.61 ± 0.15 | BL6 vs FKRP-treadmill: p < 0.001, FKRP vs FKRP-treadmill: p < 0.05 |
GAS | 3 | 0.47 ± 0.23 | 3 | 46.18 ± 5.4 | 3 | 38.44 ± 5.1 | NP | |
% central nucleation | Quad | 3 | 0.2 ± 0.3 | 3 | 56.0 ± 1.9 | 3 | 51.1 ± 2.1 | NP |
Triceps | 3 | 1.44 ± 1.11 | 3 | 65.71 ± 1.1 | 3 | 75.16 ± 8.4 | NP | |
GAS | 3 | 34.27 ± 0.7 | 3 | 37.9 ± 3.6 | 3 | 42.7 ± 2.6 | NP | |
Fiber diameter size (μm) | Quad | 3 | 48.2 ± 5.5 | 3 | 44.8 ± 1.2 | 3 | 49.7 ± 1.6 | NP |
Triceps | 3 | 37.75 ± 1.2 | 3 | 37.03 ± 1.8 | 3 | 43.70 ± 2.0 | NP | |
GAS | 3 | 0.5 ± 0.2 | 3 | 7.6 ± 5.4 | 3 | 10.7 ± 5.1 | NP | |
SD of % central nucleation | Quad | 3 | 0.4 ± 0.5 | 3 | 8.9 ± 3.9 | 3 | 12.6 ± 4.4 | NP |
Triceps | 3 | 1.28 ± 1.1 | 3 | 15.94 ± 1.1 | 3 | 8.17 ± 8.4 | NP | |
GAS | 3 | 1.93 ± 0.7 | 3 | 8.5 ± 3.6 | 3 | 8.73 ± 2.6 | NP | |
SD of fiber size | Quad | 3 | 11.8 ± 1.3 | 3 | 20.5 ± 1.8 | 3 | 21.5 ± 1.9 | NP |
Triceps | 3 | 1.93 ± 1.2 | 3 | 4.8 ± 1.8 | 3 | 6.96 ± 2.0 | NP | |
Serum creatinine kinase(μ/l) | 8 | 254 ± 131 | 7 | 749 ± 405 | 12 | 947 ± 575 | BL6 VS. FKRP-treadmill: p < 0.05 |