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Fig. 6 | Skeletal Muscle

Fig. 6

From: An RNAi based screen in Drosophila larvae identifies fascin as a regulator of myoblast fusion and myotendinous junction structure

Fig. 6

Muscle-specific depletion of fascin results in smaller muscles with fewer nuclei. ac Immunofluorescence images of the VL3 muscle in L3 larvae that expressed RNAi against either mCherry (control) or fascin (sn RNAi) under the control of Twist-GAL4 (a), DMef2-GAL4 (b), or MHC-GAL4 (c). Sarcomeres were identified by Phalloidin (magenta), and nuclei were identified by Hoechst (green). Scale bar, 25 μm. d Graph indicating the actual internuclear distance divided by the maximal internuclear distance in indicated genotypes. e Graph indicating the area of the muscles in larvae of indicated genotypes. f Graph indicating the number of nuclei per muscle in larvae of indicated genotypes. All data (de) were compared to their control by Student’s t test. *p < 0.05; **p < 0.01; ****p < 0.0001

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