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Fig. 10 | Skeletal Muscle

Fig. 10

From: Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?

Fig. 10

Architecture and membrane topology of the Cav1.1. a Side view of a cryo-EM reconstruction of the Cav1.1 and its subunits at 3.6 Å (Protein Data Bank (PDB) 5GJW) [100]. The Cav1.1 α1 subunit is highlighted in blue. Auxiliary β-, α2δ-, and γ-subunits are colored in green, red, and yellow, respectively. This model was created in Chimera [174]. The asterisk symbol indicates the missing II–III loop sequence in the cryo-EM structure. b Membrane topology of the Cav1.1 α1 subunits. The α1 subunit is composed by an interconnect array of four homologous (but not identical) domains, each domain consisting of six transmembrane domains, S1–S6. S1–S4 from each domain form a voltage sensor domain, whereas S5 and S6 from all four domains form the pore domain. Intracellular loops connect the domains; the loops II–III and I–II are important for ECC, as indicated

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