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Fig. 11 | Skeletal Muscle

Fig. 11

From: Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?

Fig. 11

Structural details of the Cav1.1 α1 subunit and the RyR1. a Shown are cryo-EM reconstructions of the Cav1.1 a subunit, side view (top) and upper view (bottom) (PDB 5GJW) [100]. The auxiliary subunits, the cytoplasmic tails, and loops are not shown. Each domain is color coded, positively charged residues are indicated in red, negatively charged residues are shown in blue. The dashed ellipse indicates the location of S1–S4 from domain I and the black circle shows the corresponding pore domain (S5–S6) from domain I. Note that each voltage sensor domain (S1–S4) is not in close proximity to its corresponding pore domain (S5–S6). b Side (top) and upper (bottom) views of cryo-EM reconstruction of the RyR1 (PDB, 5TAL) [175] and four superimposed Cav1.1 α1 subunits (PDB 5GJW) [100], forming a tetrad. This model was created in Chimera [174] using the cryo-EM maps with relative location of the Cav1.1 subunits as suggested by Samsó [118]

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