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Fig. 5 | Skeletal Muscle

Fig. 5

From: Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?

Fig. 5

Cav1.1 (pale blue) serves as voltage sensor for two different Ca2+ channels: its own intramolecular Ca2+ channel in the TT membrane (current illustrated in blue) and the RyR1 Ca2+ release channel (tan) in the SR membrane (current illustrated in red). Cartoon representation of the simplest gating mechanism. RyR1 Ca2+ channel is directly controlled by molecular coupling of Cav1.1 to RyR1. Note that Ca2+ influx via the TT Cav1.1 Ca2+ channel is not needed for activation of the RyR1 SR Ca2+ release channel

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Skeletal Muscle

ISSN: 2044-5040

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