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Fig. 8 | Skeletal Muscle

Fig. 8

From: Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?

Fig. 8

Empirical evidence for a model for activation of each RyR1 in which four identical and independent voltage sensors must all be in the active configuration for the SR Ca2+ release channel to open after pre-inactivation of the RyR1 channel. a Ca2+ transients (top) and calculated rate of SR Ca2+ release (middle) for the pulse protocol at the bottom. Pulses to various test pulse amplitudes were each preceded by the same inactivating prepulse, followed by brief return to the holding potential to reset the voltage sensors and close the RyR1 channel and then the various depolarizations (bottom). b Wave form of Ca2+ release during the test pulses closely follows Q4. c Voltage dependence of Ca2+ released follows the fourth power of charge moved (dashed curve). From ref. [88], with modification

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