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Fig. 9 | Skeletal Muscle

Fig. 9

From: Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?

Fig. 9

Allosteric model for gating of each coupled RyR1 by four different voltage sensors. a Cartoon of a single RyR1 homo-tetramer controlled by four independent voltage sensors, with all four voltage sensors in the inactive configuration (left) or with one voltage sensor in the activated configuration (right). b Kinetic reaction scheme for the RyR1 Ca2+ channel gating process. Channel opening becomes more likely as more voltage sensors become active, which is the basis for the allosteric effect. However, the channel can open with any number of voltage sensors active. The subscript i on C or O is the number of voltage sensors active. Forward rate constant k for Ci → Oi increases with i; the backward rate constant k for Oi → Ci decreases with i. Note that f < 1. Elimination of states O0 to O3 from this scheme reduces it to the model proposed in Fig. 8. From ref. [92], with modification

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