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Fig. 3 | Skeletal Muscle

Fig. 3

From: Biochemical and pathological changes result from mutated Caveolin-3 in muscle

Fig. 3

Expression of p.P104L missense mutant CAV3 disturbs ER-Golgi integrity. (a) EM findings in p.P104L CAV3 mutant quadriceps muscle: subsarcolemmal accumulation of vesicular structures (most likely corresponding to abnormal caveolae) (black arrows in 3A.1 and 3A.2) and dispersed ERGIC-Golgi structures (black arrows in 3A.3 – 3A.5). (b) Immunohistochemical studies focusing on ER-Golgi stress confirm GM130 increase. (c) Immunofluorescence studies focusing on Golgi-structure in 6 month and 1 year old animals (visualization via golgin-97 staining) revealed a statistically significant dispersion on p.P104L CAV3 transgenic animals

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