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Fig. 2 | Skeletal Muscle

Fig. 2

From: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

Fig. 2

Prolyl hydroxylase inhibitors exert their protective effects independently of EPO. a Serum EPO concentration and b Serum VEGF concentration after oral administration of 10 mg/kg GSK360 in mice (n = 8). c Force deficit 24 h after eccentric injury. Mice were treated daily with rEPO, with and without an EPO neutralizing antibody (n = 8). d Force deficit 24 h after eccentric injury of mice co-treated with EPO neutralizing antibody and GSK360 (n = 8). e Force deficit 24 h after eccentric injury of mice co-treated with soluble EPO receptor and GSK360 (n = 8). f Western blot of HIF1α protein levels from muscle lysates 1 h and 24 h after limb injury. GAPDH used as a loading control

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