Fig. 4
From: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Prolyl hydroxylase inhibitor daprodustat reduces markers of muscle damage in healthy male volunteers after eccentric exercise. a Clinical study design. b Maximum voluntary force at an arm angle of 90o before and after eccentric exercise in two separate studies. Boxed area represents a 75% range of values; central line indicates the median and the cross the mean value. Individual values are displayed to the left (top figure, placebo n = 14, daprodustat 5 mg n = 12; bottom figure, placebo n = 15, daprodustat 50 mg n = 15). c Serum creatine kinase before and after eccentric exercise in the two separate studies. d Heatmap and hierarchical clustering of the top 16 serum proteins changed between pre-exercise and 3 days post exercise and the effect of 50 mg daprodustat on their levels. The first two columns display fold changes pre- vs. postexercise for daprodustat-treated and placebo-treated participants, respectively. The third column shows daprodustat fold change treated vs. placebo-treated samples postexercise. Protein names in bold denote a significant association with muscle-related phenotypes and/or pathways (each group n = 15). All data in the figure are shown as the mean ± SEM. Repeat measure ANOVA for multiple comparisons; ***P < 0.001)