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Fig. 4 | Skeletal Muscle

Fig. 4

From: Dystrophin R16/17-syntrophin PDZ fusion protein restores sarcolemmal nNOSμ

Fig. 4

The R16/17-Syn PDZ fusion protein restored sarcolemmal nNOSμ in Cmah/mdx and DBA/2 J-mdx mice. AAV viruses were injected into both TA muscles of three Cmah/mdx (n = 3) and three DBA/2 J-mdx mice (n = 3). Representative photomicrographs of serial muscle sections visualized for GFP, R17, syntrophin (Syn), nNOS expression, and nNOS activity staining. In non-transduced myofibers, there is no sarcolemmal nNOSμ restoration. Asterisk, the same myofiber in serial sections; square, the non-transduced myofiber. Scale bar = 50 μm

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