From: β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
WT | βarr1KO | P value | ||||
---|---|---|---|---|---|---|
Vehicle | Clenbuterol | Vehicle | Clenbuterol | Drug | Strain | |
EDL | ||||||
I (%) | 0.0 ± 0.0 | 0.1 ± 0.1 | 0.3 ± 0.2 | 0.9 ± 0.5 | ||
IIa (%) | 12.7 ± 1.6 | 11.4 ± 1.4 | 13.7 ± 1.3 | 9.6 ± 1.7 * | ||
IIb (%) | 59.2 ± 3.7 | 68.4 ± 3.3 * | 65.2 ± 2.3 | 73.7 ± 2.8 ** | * | |
IIx (%) | 28.1 ± 4.9 | 20.1 ± 2.1 ** | 20.8 ± 1.9 | 15.8 ± 2.2 * | * | |
I + IIa (%) | 12.7 ± 1.6 | 11.5 ± 1.2 | 14.0 ± 1.4 | 10.5 ± 1.3 * | ||
IIb + IIx (%) | 87.3 ± 1.6 | 88.5 ± 1.2 | 86.0 ± 1.4 | 89.5 ± 1.3 * | ||
N | 7 | 8 | 7 | 8 | ||
Soleus | ||||||
I (%) | 48.8 ± 1.4 | 44.2 ± 1.8 | 48.9 ± 3.6 | 51.0 ± 2.0 | ||
IIa (%) | 44.6 ± 1.6 | 44.5 ± 1.4 | 42.8 ± 3.3 | 36.6 ± 1.7 | * | |
IIb (%) | 0.0 ± 0.0 | 2.5 ± 0.8 * | 1.3 ± 0.8 | 5.0 ± 1.2 * | ** | * |
IIx (%) | 6.7 ± 1.1 | 8.8 ± 0.9 | 7.0 ± 1.2 | 7.4 ± 1.2 | ||
I + IIa (%) | 93.3 ± 1.1 | 88.8 ± 1.1 * | 91.8 ± 1.3 | 87.6 ± 1.1 * | ** | |
IIb + IIx (%) | 6.7 ± 1.1 | 11.3 ± 1.1 * | 8.2 ± 1.3 | 12.4 ± 1.1* | ** | |
N | 6 | 8 | 7 | 8 | ||
Plantaris | ||||||
I (%) | 0.0 ± 0.0 | 0.5 ± 1.2 | 2.9 ± 0.6 | 1.2 ± 0.3 | * | |
IIa (%) | 33.3 ± 2.2 | 25.8 ± 2.0 * | 23.7 ± 3.3 | 20.2 ± 0.8 | * | ** |
IIb (%) | 48.2 ± 3.7 | 58.3 ± 3.2 * | 52.2 ± 4.7 | 68.5 ± 1.3 ** | *** | * |
IIx (%) | 18.6 ± 2.3 | 15.1 ± 2.6 | 21.2 ± 1.5 | 10.2 ± 1.0 ** | ** | |
I + IIa (%) | 33.3 ± 2.4 | 26.2 ± 2.0 * | 26.6 ± 3.5 | 21.4 ± 0.8 | * | * |
IIb + IIx (%) | 66.7 ± 2.4 | 73.8 ± 2.0 * | 73.4 ± 3.5 | 78.6 ± 0.8 | * | * |
N | 7 | 8 | 7 | 8 |