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Fig. 3 | Skeletal Muscle

Fig. 3

From: Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation

Fig. 3

Histological maladaptations in t/t LG muscle. Average cross-sectional area (CSA) of individual muscle fibers (a) and their size distribution (b) were evaluated in over 500 fibers from each sample. c H&E staining (top) and immunohistology (eMHC; green, dystrophin; red, and DAPI; blue, bottom) of cross-sectioned LG muscle. d, e Numbers of central nuclei (CN, d) and eMHC+ fibers (e) were counted on whole muscle cross-section and normalized by mm2 area. Arrowhead indicates CN (scale bar: 50 um). *P < 0.05 and **P < 0.01. n = 3 muscle samples of each genotype. An average of 521 ± 11 fibers from five different areas of each slide were used for analysis

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