Fig. 4
From: Late-onset megaconial myopathy in mice lacking group I Paks
Identification of megaconial mitochondria in dKO muscle. a Electron micrographs of longitudinal sections of a 12-month control and dKO TA and quadriceps. Megaconial mitochondria (open arrow) and subsarcolemmal accumulation of mitochondria (closed arrow) are indicated in dKO mice. 500-nm scale bar pertains to all micrographs except the lower right panel, where the indicated bar represents 2 μm. Quantitative analysis of the number of mitochondria per unit area (b), the percentage of megaconial mitochondria (c), and the proportion of mitochondria of the indicated size (d), all as assessed by analyses of electron micrographs. For each genotype, two individual animals are depicted by a black circle or triangle, each point representing the count from randomly selected, independent sections of different myofibers