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Fig. 7 | Skeletal Muscle

Fig. 7

From: Late-onset megaconial myopathy in mice lacking group I Paks

Fig. 7

Analysis of choline kinase activity in control and dKO mice and Pak1/2 phosphorylation in control and rmd mice. a Ratio of phosphocholine (pCholine) to total choline (left graph) and total phosphatidylcholine (PC) levels (right graph) in the forelimb and hindlimb (quadriceps) muscles of three independent 1-year-old control and dKO mice quantified by mass spectrometry. Histograms represent means ± SD. b Western blot analysis of activated Pak1 and Pak2 in the forelimb and hindlimb muscle from P11 control and rmd/rmd mice. For all western blot analyses, 150 μg of protein were loaded per sample. Three mice of each genotype are shown. c Densitometric quantification of the results in b and similar western blots; Gapdh was used for normalization. n = 3, *p < 0.05

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