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Fig. 1 | Skeletal Muscle

Fig. 1

From: Exogenous expression of the glycosyltransferase LARGE1 restores α-dystroglycan matriglycan and laminin binding in rhabdomyosarcoma

Fig. 1

Immunohistochemical staining for α-dystroglycan matriglycan in skeletal muscle and RMS. ac Representative images of immunohistochemistry for matriglycan (antibody IIH6) staining of a control human skeletal muscle, b aRMS, and c eRMS. n = 55 aRMS, n = 14 eRMS. df Western blotting of tumor lysates for d core dystroglycan (antibody AP83), e matriglycan-modified dystroglycan (antibody IIH6), and f laminin-bound dystroglycan (anti-myc, recognizing myc-tagged LG4-5 domains of laminin α1). SkM skeletal muscle. PCB69, eRMS 1.7-yo male. PCB178, eRMS 3-yo male. PCB42, aRMS 9-yo male (fusion unknown). PCB481, aRMS 14-yo male (Pax3:Foxo1+). CF1, aRMS 2-yo male (Pax3:Foxo1). CF2, 7-yo female (Pax7:Foxo1). PCB117, rhabdomyoma 57-yo female

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