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Fig. 5 | Skeletal Muscle

Fig. 5

From: Muscle injury-induced hypoxia alters the proliferation and differentiation potentials of muscle resident stromal cells

Fig. 5

Hypoxia promotes the osteogenic differentiation of mrSCs. Representative micrograph of the in vitro adipogenic and osteogenic differentiation potentials of mrSCs that were isolated from control muscle and that were differentiated in normoxic incubator condition (called “Normoxia”) or hypoxia. In normoxic incubator condition, the mrSCs differentiated into adipocytes but not into osteoblasts, as indicated by Oil Red O and Alizarin Red S staining, respectively. On the other hand, hypoxia supported osteogenic differentiation at the expense of adipogenic differentiation. Osteogenic differentiation was possible even without the addition of an osteoinductive agent such as BMP9. The results are representative of four independent experiments (n = 3–4/experiment)

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