TY - JOUR AU - Bailey, Erin C. AU - Alrowaished, Sarah S. AU - Kilroy, Elisabeth A. AU - Crooks, Emma S. AU - Drinkert, Daisy M. AU - Karunasiri, Chaya M. AU - Belanger, Joseph J. AU - Khalil, Andre AU - Kelley, Joshua B. AU - Henry, Clarissa A. PY - 2019 DA - 2019/08/07 TI - NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy JO - Skeletal Muscle SP - 21 VL - 9 IS - 1 AB - Secondary dystroglycanopathies are muscular dystrophies that result from mutations in genes that participate in Dystroglycan glycosylation. Glycosylation of Dystroglycan is essential for muscle fibers to adhere to the muscle extracellular matrix (myomatrix). Although the myomatrix is disrupted in a number of secondary dystroglycanopathies, it is unknown whether improving the myomatrix is beneficial for these conditions. We previously determined that either NAD+ supplementation or overexpression of Paxillin are sufficient to improve muscle structure and the myomatrix in a zebrafish model of primary dystroglycanopathy. Here, we investigate how these modulations affect neuromuscular phenotypes in zebrafish fukutin-related protein (fkrp) morphants modeling FKRP-associated secondary dystroglycanopathy. SN - 2044-5040 UR - https://doi.org/10.1186/s13395-019-0206-1 DO - 10.1186/s13395-019-0206-1 ID - Bailey2019 ER -