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Fig. 5 | Skeletal Muscle

Fig. 5

From: Two functional variants at 6p21.1 were associated with lean mass

Fig. 5

Dual-luciferase reporter assay. The pGL3-promoter vector was set as negative control (NC). Four replicates were conducted under each condition. Compared with the NC vector, the vector containing either rs524533 or rs571770 largely decreases luciferase expression (p = 1.07 × 10−5–5.33 × 10−6). At rs524533, the decrease for allele C construct is less than that for allele T construct by 4.7-fold (p = 8.41 × 10−4). At rs571770, the decrease for allele C construct is less than that for allele G construct by 2.5-fold (p = 4.09 × 10−3). **p < 0.01; ***p < 0.001

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