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Table 1 Main association results of leg lean mass at 6p21.1

From: Two functional variants at 6p21.1 were associated with lean mass

SNP

Position

Alleles

EAF

FHS (N = 6587)

WHI-AA (N = 847)

KCOS (N = 2219)

GIANT+UKB (BMI)

Beta

p

Beta

p*

Beta

p*

Beta

p

N

rs551145

44237448

C/T

0.75

0.10

3.40 × 10−9

0.27

2.25 × 10−3

0.08

8.49 × 10−3

-

-

-

rs545970

44239677

C/G

0.31

− 0.10

7.46 × 10−9

− 0.11

0.04

− 0.07

0.02

− 0.01

7.00 × 10−3

634887

rs571770

44240193

C/G

0.31

− 0.10

9.02 × 10−9

− 0.19

5.97 × 10−3

− 0.07

0.01

− 4.80 × 10−3

9.80 × 10−3

688916

rs524533

44240559

C/T

0.42

− 0.10

9.77 × 10−9

− 0.23

1.61 × 10−3

− 0.07

0.02

− 0.01

7.80 × 10−3

687217

  1. Physical position is based on the human genome GRCH37 assembly. The first and second alleles are the effect and the other alleles. EAF: effect allele frequency in the European population. Beta: regression coefficient of the effect allele. FHS, Framingham Heart Study; WHI-AA, Women’s Health Initiative–African American sub sample; KCOS, Kansas City Osteoporosis Study; UKB. UK Biobank. The joint analysis of the GIANT and the UKB samples represents the largest study of BMI, and is used for cross-validation of the association with leg lean mass in the present study. p values below the genome-wide significance level (5.0 × 10−8) are set in italics. “-,” not available; “p*,” one-sided p value