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Table 1 Main association results of leg lean mass at 6p21.1

From: Two functional variants at 6p21.1 were associated with lean mass

SNPPositionAllelesEAFFHS (N = 6587)WHI-AA (N = 847)KCOS (N = 2219)GIANT+UKB (BMI)
BetapBetap*Betap*BetapN
rs55114544237448C/T0.750.103.40 × 10−90.272.25 × 10−30.088.49 × 10−3---
rs54597044239677C/G0.31− 0.107.46 × 10−9− 0.110.04− 0.070.02− 0.017.00 × 10−3634887
rs57177044240193C/G0.31− 0.109.02 × 10−9− 0.195.97 × 10−3− 0.070.01− 4.80 × 10−39.80 × 10−3688916
rs52453344240559C/T0.42− 0.109.77 × 10−9− 0.231.61 × 10−3− 0.070.02− 0.017.80 × 10−3687217
  1. Physical position is based on the human genome GRCH37 assembly. The first and second alleles are the effect and the other alleles. EAF: effect allele frequency in the European population. Beta: regression coefficient of the effect allele. FHS, Framingham Heart Study; WHI-AA, Women’s Health Initiative–African American sub sample; KCOS, Kansas City Osteoporosis Study; UKB. UK Biobank. The joint analysis of the GIANT and the UKB samples represents the largest study of BMI, and is used for cross-validation of the association with leg lean mass in the present study. p values below the genome-wide significance level (5.0 × 10−8) are set in italics. “-,” not available; “p*,” one-sided p value