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Table 2 Validated hits from hSSPN-EGFP screen reveal enrichment of calcium channel blockers

From: Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy

Compound

Description

Felodipine

L-type Ca2 + channel blocker

GW5074

cRaf1 kinase inhibitor

Isoproterenol

Sympathomimetic amine acting on β-adrenoceptors

Isradipine

L-type Ca2 + channel blocker

Lacidipine

L-type Ca2 + channel blocker

Nandrolone

Anabolic-androgenic steroid

Nilvadipine

L-type Ca2 + channel blocker

  1. The screen resulted in 13 initial hits, which were further validated with the hSSPN-EGFP reporter with an n = 24. The 7 validated hits included an overrepresented number of L-type calcium channel blockers
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Skeletal Muscle

ISSN: 2044-5040

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