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Fig. 6 | Skeletal Muscle

Fig. 6

From: Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function

Fig. 6

Myosin heavy chain composition. a Representative acrylamide gel depicting separation of myosin heavy chain (MHC) isoforms. Left four columns are vehicle-treated (LEDL, LTC) and AAV-treated (REDL, RTC) CTRL mice. Middle column is a mixture of TC and soleus muscle from a C57BL/6 mouse serving as a marker for the isoforms. Right four columns are vehicle-treated (LEDL, LTC) and AAV-treated (REDL, RTC) Neb cKO mice. b Quantification of MHC composition in vehicle-treated and AAV-treated CTRL TCs and EDLs (1× dosage). A significant increase in Type IIA/X MHC and a significant decrease in Type IIB MHC occur in the EDLs. TCs trend in the same direction (n = 6 mice). c Quantification of MHC composition in vehicle-treated and AAV-treated Neb cKO TCs and EDLs (1× dosage). A significant increase in Type IIB MHC and trend toward a reduced MHC I (n = 9 mice). (Paired t tests were used in these analyses)

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Skeletal Muscle

ISSN: 2044-5040

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