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Fig. 9 | Skeletal Muscle

Fig. 9

From: Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function

Fig. 9

Expression of regulatory proteins in response to AAV treatment. a A representative Western blot depicting NRAP expression, KLHL41 expression, and GAPDH expression in vehicle-treated (LEDL, LTC) and AAV-treated (REDL, RTC) CTRL and Neb cKO mice. b Changes in KLHL41 expression following AAV treatment. Both CTRL and Neb cKO TC muscles experience an increase in protein expression. Similarly, CTRL EDL muscles experience an increase, but Neb cKO EDL muscles remain unchanged. c Changes in NRAP expression following AAV treatment. While CTRL TC muscles experience a trending increase toward higher expression, control EDL muscles have a significant increase in protein expression. Neb cKO EDL muscles experience a significant decrease in NRAP protein. (n = 5, 6 mice)

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