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Fig. 3 | Skeletal Muscle

Fig. 3

From: Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity

Fig. 3

DUX4-FL target genes, but not DUX4-fl mRNA, show TMX dose-dependent increased expression. Gastrocnemius muscles from 13–14-week-old female mice isolated 9 days after TMX administration were assayed for gene expression levels by qRT-PCR. a Levels of DUX4-fl mRNA are not significantly different between the FLExD mice and the three bi-transgenic models. However, mRNA expression of bWdfc3 and cTrim36 are increased significantly in all bi-transgenic models compared with FLExD. Both Wdfc3 and Trim36 are significantly increased by moderate and severe TMX induction compared with no TMX. Trim36 mRNA levels are significantly increased in the severe compared to moderate models. All expression is normalized to RpL37 expression. MT, equivalent level of cDNA from 17Abic FSHD1 myotubes [18]. Data are mean ± S.D. with significance calculated using Welch’s t test, *p < 0.05, **p < 0.01

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Skeletal Muscle

ISSN: 2044-5040

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