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Fig. 6 | Skeletal Muscle

Fig. 6

From: Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity

Fig. 6

Comparison of gene expression in muscle from FSHD-like models compared with controls. ad Scatter plots showing differentially expressed genes in RNA-seq data derived from gastrocnemius muscles isolated from aFLExD/+ mice, b bi-transgenic mild model mice, c bi-transgenic moderate model mice, and d bi-transgenic severe model mice (y-axis), each compared with ACTA1-MCM control mice (x-axis). Significantly upregulated genes are indicated in red, and downregulated genes are indicated in blue. eh Above scatter plots highlighting the DUX4-induced genes similarly induced by DUX4 in C2C12 myoblasts [25]

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