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Fig. 7 | Skeletal Muscle

Fig. 7

From: Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity

Fig. 7

GO enrichment analysis of differentially expressed genes in FSHD-like severity model mice. GO enrichment analysis for DUX4-induced genes identified in (left to right) C2C12 cells [25], mild FSHD-like mice, moderate FSHD-like model mice, and severe FSHD-like model mice. The size of the beige-colored circles indicates the total number of differentially expressed genes (> 1.4-fold), colored circles indicate the proportion of genes from significantly enriched GO terms, that are in turn offspring of GO superterms (see the “Methods” section and Table S4) relating to mus. Upregulated genes are represented in the top half and downregulated genes are represented in the lower half. The number of genes in each grouping is indicated (n)

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Skeletal Muscle

ISSN: 2044-5040

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