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Fig. 8 | Skeletal Muscle

Fig. 8

From: Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity

Fig. 8

Skeletal muscles from the mild and moderately affected FSHD-like mouse models show signs of dystrophic histopathology. Representative cryosections of tibialis anterior, gastrocnemius, soleus, and quadriceps of indicated transgenic animals were analyzed with H&E staining. Female (ad) ACTA1-MCM mice treated with 1× 5 mg/kg TMX, (eh) mild model bi-transgenic mice without TMX, and (ix) moderate model bi-transgenic mice treated 1× with 5 mg/kg TMX. The TMX-injected ACTA1-MCM control mice were assayed at MD28. The TMX-injected bi-transgenic mice were assayed at (il) MD3, (mp) MD6, (qt) MD14, and (ux) MD 28. All mice had performed the treadmill exhaustion analysis, as described, 2× per week starting the week prior to TMX injection. Scale bar = 100 μm

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