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Fig. 9 | Skeletal Muscle

Fig. 9

From: Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity

Fig. 9

Skeletal muscle from the severely affected FSHD-like mice shows signs of a severe myopathy. Representative cryosections of tibialis anterior, gastrocnemius, soleus, and quadriceps from indicated transgenic animals were analyzed with H&E staining. adACTA1-MCM mice treated with 2× 10 mg/kg TMX, eh mild model bi-transgenic mice without TMX, and (it) severe model bi-transgenic mice treated 2× with 10 mg/kg TMX. The TMX-injected controls were assayed at SD9. The TMX-injected bi-transgenic mice were assayed at (il) SD3, (mp) SD6, and (qt) SD9. All mice had performed the treadmill exhaustion analysis, as described, 1 week prior to TMX injection, then 2, 5, and 7 DPI. Scale bar = 100 μm

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