Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity

Table 2 GO superterms enriched in FSHD-like models

Comparison	Status	GO superterm	% of genes associated^a
iDUX4 Dox vs vehicle	Up	Apoptosis	16.42
iDUX4 Dox vs vehicle	Up	Cell cycle	12.55
iDUX4 Dox vs vehicle	Up	Immune	0.53
iDUX4 Dox vs vehicle	Down	Cell cycle	39.25
iDUX4 Dox vs vehicle	Down	Immune	7.07
iDUX4 Dox vs vehicle	Down	Muscle	4.99
Moderate model vs MCM	Up	Immune	30.06
Moderate model vs MCM	Up	Cell cycle	24.91
Moderate model vs MCM	Up	Apoptosis	10.29
Moderate model vs MCM	Down	Muscle	8.23
Severe model vs MCM	Up	Immune	31.05
Severe model vs MCM	Up	Cell cycle	26.43
Severe model vs MCM	Up	Apoptosis	16.95
Severe model vs MCM	Up	Muscle	0.70
Severe model vs MCM	Down	Muscle	14.84

ISSN: 2044-5040