Fig. 4

Twenty-four-month-old MCKa animals have worsened age-associated trabecular bone loss. a Quantification of average trabecular number and trabecular separation in isolated femurs from 24-month-old male mice. b Quantification of average cortical bone area and cortical bone thickness in isolated femurs from 24-month-old male mice. c Micro-computed topography (micro-CT)-generated 3-dimensional scans of trabecular and cortical bone in isolated femurs. d Maximum flexural stress, elasticity, and flexural roughness of isolated femurs from 24-month-old male mice. e qPCR of Fndc5 in quadriceps isolated from 24-month-old male mice [n = 5, 5 for 24-month-old WT and MCKa]. *P < 0.05 compared to control