Fig. 5
[Ca2+]i transient kinetics are slowed in SMA cardiomyocytes. a Representative [Ca2+]i transient measured in ventricular myocytes isolated from SMA or unaffected hearts (aged P12–13). There was no significant difference in the estimated diastolic or peak systolic [Ca2+]i (n = 21 for both SMA and control). b Typical normalized [Ca2+]i transients from SMA and control cells are shown illustrating that the time to 50% removal of cytoplasmic Ca2+ (T50) c was significantly increased in SMA myocytes compared to control in agreement with the slowed relaxation kinetics. Statistical analysis: p values shown for t test, n = 41 and 39 for SMA and control, respectively