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Fig. 3 | Skeletal Muscle

Fig. 3

From: Pluripotent stem cell-derived skeletal muscle fibers preferentially express myosin heavy-chain isoforms associated with slow and oxidative muscles

Fig. 3

PSC-derived skeletal muscle fibers express genes associated with mitochondrial function. a Plot shows gene ontology cellular components terms, ranked based on hierarchy, of the genes upregulated in PSC-derived iPax3 and iPax7 myogenic progenitors. Black bars indicate p value in logarithmic scale representing B+H FDR. Red boxes highlight mitochondrial specific categories. b Graphs show the average count per million (CPM) values for representative differentially expressed genes from the categories highlighted in panel a. Data are shown as mean ± SEM (n = 4 per group). ***p < 0.001 and ****p < 0.0001. c Graph shows RT-qPCR results of mRNA expression levels of the genes for ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (Atp5c1), cytochrome c oxidase subunit 5A (Cox5a), and cytochrome c1 (Cyc1). Data are shown as mean ± SEM (n = 4 per group). **p < 0.01. iPax3 TA, NSGmdx4cv muscles injected with iPax3 myogenic progenitors; ctrl TA, non-injected muscles of 3-month-old NSGmdx4cv mice

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