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Fig. 1 | Skeletal Muscle

Fig. 1

From: Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD

Fig. 1

The NODScid dyW mouse model of LAMA2-CMD shows downregulated levels of laminin-α2 protein chain and is immunodeficient. a Detection of laminin-α2 (red) in tibialis anterior (TA) sections of wild-type, dyW internal control, dyW, and NODScid dyW. Scale bar 100 μm. b Relative levels of immunoglobulin in sera of wild-type, NOD Scid, dyW, and NODScid dyW (N = 9; p value < 0.0001). c Fluorescence-activated cell sorting (FACS) gate analysis of hematopoietic cells (CD45+) from sera of wild-type and NODScid dyW co-labeled with T cell marker (CD3ε+) and B cell marker (CD19+)

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Skeletal Muscle

ISSN: 2044-5040

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