Fig. 1

Single-cell transcriptomic map of human muscle tissue biopsies. a Metadata (sex, age, anatomical site, and the number of single-cell transcriptomes after quality control (QC) filtering) from n = 10 donors. Colors indicate sample anatomical sites. b Scanorama-integrated and batch-effect corrected transcriptomic atlas revealing a consensus description of 16 distinct muscle-tissue cell populations. c Transcriptomic atlas colored by donor and anatomical location. d Dot-plot showing differentially expressed genes that distinguish the cell populations. Grouped in four compartments: muscle, endothelial/vascular, stromal, and immune. e Cell type proportions as annotated in (b) across the 10 donors and grouped by body sections. L, leg (donors 02, 07, 08); T, trunk (donors 01, 05, 06, 09, 10); F, face (donors 03, 04)