Line name (n) | Work (nJ/mm3) | Power (W/m3) | fwmax (Hz) | %ML |
|---|
pwMhc2/+pwMhc2 (13) | 2.7 ± 0.3 | 392 ± 41 | 150 ± 8 | 0.75 ± 0.18 |
F437I/+pwMhc2 (12) | 1.4 ± 0.3* | 151 ± 25** | 117 ± 11** | 0.75 ± 0.00 |
pwMhc2/+pwMhc2 (12) | 2.5 ± 0.2 | 370 ± 40 | 150 | 0.75 |
F437I/+pwMhc2 (6) | 0.9 ± 0.7* | 134 ± 46** | 150 | 0.75 |
- Workloop analysis of isolated fibers from mutant heterozygote and wild-type control fibers. For the top 2 rows, optimal muscle length oscillation frequency (fwmax), and % muscle length (%ML) change were varied until maximum power was generated by the fiber. In the bottom 2 rows fwmax and %ML were set at the values that produced maximum power for the control line and the resulting work and power recorded. Values are mean ± standard errors of the mean. Statistically significant differences between mutant and wild-type fibers were found for work, power, and fwmax (top two lines) and for work and power at 150 Hz and 0.75% ML (lower two lines) (* = P < 0.05, ** = P < 0.01, Student’s t test)
