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Table 3 Workloop analysis of IFM fibers from 2-day-old control and F437I heterozygote female flies

From: Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism

Line name (n) Work (nJ/mm3) Power (W/m3) fwmax (Hz) %ML
pwMhc2/+pwMhc2 (13) 2.7 ± 0.3 392 ± 41 150 ± 8 0.75 ± 0.18
F437I/+pwMhc2 (12) 1.4 ± 0.3* 151 ± 25** 117 ± 11** 0.75 ± 0.00
pwMhc2/+pwMhc2 (12) 2.5 ± 0.2 370 ± 40 150 0.75
F437I/+pwMhc2 (6) 0.9 ± 0.7* 134 ± 46** 150 0.75
  1. Workloop analysis of isolated fibers from mutant heterozygote and wild-type control fibers. For the top 2 rows, optimal muscle length oscillation frequency (fwmax), and % muscle length (%ML) change were varied until maximum power was generated by the fiber. In the bottom 2 rows fwmax and %ML were set at the values that produced maximum power for the control line and the resulting work and power recorded. Values are mean ± standard errors of the mean. Statistically significant differences between mutant and wild-type fibers were found for work, power, and fwmax (top two lines) and for work and power at 150 Hz and 0.75% ML (lower two lines) (* = P < 0.05, ** = P < 0.01, Student’s t test)