Fig. 3
From: Mitochondrial dysfunction and consequences in calpain-3-deficient muscle
Capn3 deficiency induces a deficiency in mitochondrial biogenesis in vitro. Analysis of the mitochondrial DNA-to-nuclear DNA ratio in WT (Capn3+/+) and Capn3-deficient (Capn3−/−) myoblasts. The RT-qPCR analysis was performed on n = 2 flasks for Capn3+/+ and n = 6 for Capn3−/− (a). Flow cytometry analysis of 10-nonyl acridine orange fluorescence (NAO) (cardiolipin content) in WT and Capn3−/− myoblasts (b, c). The analysis was done on n = 6 flasks per group. ***Significantly different with p < 0.001; *significantly different with p < 0.05