Fig. 5
From: Mitochondrial dysfunction and consequences in calpain-3-deficient muscle
Capn3 deficiency induces mitochondrial deficiency in vivo. Western blot of vinculin (control), TFAM, and PDK1 in the TA muscle lysates from WT (Capn3+/+) and Capn3-deficient (Capn3−/−) mice (a). Western blot quantification of TFAM expression in Capn3+/+ and Capn3−/− muscle, normalized to vinculin expression (n = 3) (b). Western blot quantification of PDK1 expression in the Capn3+/+ and Capn3−/− muscle, normalized to vinculin expression (n = 3) (c). Creatine kinase (CK) activity in the Capn3+/+ and Capn3−/− TA muscle, normalized to protein concentration (n = 8) (d). LDH activity measured in the Capn3+/+ and Capn3−/− TA muscle, normalized to protein concentration (n = 8) (e). ***Significantly different with p < 0.001; **significantly different with p < 0.01; *significantly different with p < 0.05