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Fig. 7 | Skeletal Muscle

Fig. 7

From: Mitochondrial dysfunction and consequences in calpain-3-deficient muscle

Fig. 7

The effect of enhanced mitochondrial activity on muscle phenotype in 9-month-old Capn3-deficient mice. EDL and soleus muscle mass (a) specific force in Capn3-deficient (Capn3−/−) mice treated with GW501516 (GW) or vehicle (b). Twitch-to-tetanus ratio of EDL and SOL in Capn3−/− mice treated with GW or vehicle (c). Half-relaxation time (HRT) (s) (d), time to peak twitch tension (TTP) (s), of EDL muscle (e) of GW- or vehicle-treated mice. Maximal force relative to baseline for the EDL (f) and soleus (g) muscles in Capn3−/− mice treated with GW or vehicle. The force is expressed relative to the maximal force at the beginning of the experiment. Significance indicated difference at 3 min

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