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Fig. 11 | Skeletal Muscle

Fig. 11

From: The role of Nrf2 in acute and chronic muscle injury

Fig. 11

Muscle degeneration and inflammation of WT, Nrf2tKO, mdx, and Nrf2tKOmdx mice after the long-term treadmill. (a) Grip strength test; n = 6-8. The activity of (b) LDH and (c) CK in plasma; activity assay; n = 6-8. (d) Microscopic assessment of myofiber necrosis in GM using immunofluorescent staining of IgM and IgG (green) binding and (e) its calculation; n = 6-8. (f) Microscopic assessment of myofiber necrosis in diaphragm using immunofluorescent staining of IgM and IgG (green) binding and (g) its calculation; n = 6-8. (h) Representative photos and (i) semi-quantitative analysis of inflammation in GM based on H&E staining; n = 6-8. (j) Representative photos and (k) semi-quantitative analysis of inflammation in diaphragm based on H&E staining; n = 6-8. The data are presented as mean +/− SEM; *p ≤ 0.05, **p ≤ 0.01; ***p ≤ 0.001, ****p ≤ 0.0001, one-way ANOVA with Tukey’s post hoc test; ##p ≤ 0.01 Student’s t test. The scale bars represent 100 μm

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